期刊
FOOD CHEMISTRY
卷 218, 期 -, 页码 427-434出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2016.09.066
关键词
Seaweed; Laurenciae papillosa; Bacillus amyloliquefaciens; Antibacterial metabolites; Food pathogens; Polyketides; Polyketide synthase
资金
- Indian Council of Agricultural Research Network Project High Value Compounds [HVC/ICAR 2012-2017]
- Indian Council of Agricultural Research
Heterotrophic Bacillus amyloliquefaciens associated with edible red seaweed, Laurenciae papillosa was used to isolate antibacterial polyketide compounds. Antibacterial activity studies integrated with the outcome obtained by polyketide synthetase (pks) coding genes established that seaweed-affiliated bacterial flora had a wide-ranging antibacterial activities and potential natural product diversity, which proved that the bacterium is valuable reservoir of novel bioactive metabolites. Bioactivity-guided isolation of 3-(octahydro-9-isopropyl-2H-benzo[h]chromen-4-yl)-2-methylpropyl benzoate and methyl 8-(2-(benzoyloxy)-ethyl)-hexahydro-4-((E)-pent-2-enyl)-2H-chromene-6-carboxylate of polyketide origin, with activity against human opportunistic food pathogenic microbes, have been isolated from the ethyl acetate extract of B. amyloliquefaciens. Structure-activity relationship analysis revealed that hydrophobic descriptor of the polyketide compounds significantly contribute towards its antibacterial activity. Seaweed associated microorganisms were shown to represent a potential source of antimicrobial compounds for food and health benefits. The antibacterial polyketide compounds described in the present study may find potential applications in the food industry to reduce food-borne pathogens. (C) 2016 Elsevier Ltd. All rights reserved.
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