Iron-catalyzed cross-dehydrogenative C-H amidation of benzofurans and benzothiophenes with anilines

An efficient iron-catalyzed cross-dehydrogenative aromatic C-H amidation using DDQ as an oxidant under mild conditions is reported, providing a straightforward access to structurally diverse diarylamine derivatives incorporating benzofuran/benzothiophene motifs. Mechanistic studies indicated that a nitrogen-centered anilino radical is involved in the C-N bond formation.

Automated summary

An efficient iron-catalyzed cross-dehydrogenative aromatic C-H amidation using DDQ as an oxidant under mild conditions is reported, providing a straightforward access to structurally diverse diarylamine derivatives incorporating benzofuran/benzothiophene motifs. Mechanistic studies indicated that a nitrogen-centered anilino radical is involved in the C-N bond formation.