期刊
FOOD CHEMISTRY
卷 221, 期 -, 页码 296-301出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2016.10.040
关键词
ABP-CM4; beta-Cyclodextrin; Inclusion complex; Antibacterial assay; Stability
资金
- National Natural Science Foundation of China [81501204]
Antibacterial peptide CM4 (ABP-CM4) is a natural product isolated from the silkworm Bombyx mori. It is a small cationic peptide with broad-spectrum activities against harmful microorganisms and may be used as a novel food preservative. However, ABP-CM4 lacks tertiary structure in water-like solutions, which makes it more susceptible to proteases and labile when exposed to air. In this study, beta-cyclodextrin (beta-CD) was chosen to form an inclusion complex with ABP-CM4, which enhanced the physical and chemical properties of ABP-CM4 but did not decrease its antibacterial activity. The storage stability and susceptibility to proteinases of ABP-CM4 were apparently improved under the protection of beta-CD. This technology could also be widely applied to other AMPs as an antimicrobial system to be used in the food industry. (C) 2016 Elsevier Ltd. All rights reserved.
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