Organocatalytic aminocarbonylation of α,β-unsaturated ketones with N,N-dimethyl carbamoylsilane

An organic superbase-catalyzed aminocarbonylation reaction of alpha,beta-unsaturated ketones was reported. Under the catalysis of 10 mol% Schwesinger's superbase t-Bu-P-4, a variety of enones and ynones reacted with N,N-dimethyl carbamoylsilane to afford alpha-siloxyamides or alpha-hydroxyamides in 56-82% yields.

Automated summary

An organic superbase-catalyzed aminocarbonylation reaction of alpha,beta-unsaturated ketones was reported, leading to the synthesis of alpha-siloxyamides or alpha-hydroxyamides in good yields.