Emerging on-chip surface acoustic wave technology for small biomaterials manipulation and characterization

A surface acoustic wave (SAW) is a sound wave travelling on the surface of an elastic material. SAW offers a robust control of the acoustic energy leading to an unparalleled versatility. As an actuator, SAW can exert acoustic forces on particles and fluids thus enabling dexterous micro/nanoscale manipulations. As a sensor, SAW has a unique sensing capability upon changes in the environment. On-chip SAW technology, in which SAW is integrated with modern lab-on-a-chip (LOC), has drawn a lot of attention in recent years and found various exciting applications in micro/nanosystems. In particular, its well-known biocompatibility provides on-chip SAW technology as an exceptional platform for biomaterials research at the small-scale. In this minireview, we highlighted recent advances of on-chip SAW technology for biomaterials manipulation and characterization with a focus on cell-based (e.g. single-cell and multicellular) biomaterials. We also discussed and shared our perspective on future directions for this emerging research field.

Automated summary

Surface acoustic waves (SAW) are sound waves traveling on the surface of an elastic material, offering robust control of acoustic energy and versatility. Integration of SAW with modern lab-on-a-chip technology has found numerous applications in micro/nanosystems, particularly in the field of biomaterials where SAW technology provides exceptional opportunities for research and manipulation at small scales.