期刊
FOOD CHEMISTRY
卷 235, 期 -, 页码 111-118出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2017.04.184
关键词
Antibiotics; HPLC-MS/MS; Muscle tissue; Swine; Urine
资金
- Ph.D. fellowship in Veterinary and Animal Science in the Laboratory of Inspection of Food of Animal Origin at the University of Milan, Italy
The antibiotic overuse in zoothechnics, due to prophylactic and therapeutic treatments, or to their growth-promoting activity, is a major cause for the onset of widespread antibiotic resistance. Of particular relevance to this study, is the antibiotic abuse in pig breeding. Despite the comprehensive literature on residue controls in pig muscle, data on pig urine, a non-invasive, on-farm collectable matrix, are lacking. Therefore, we validated an HPLC-MS/MS method to detect 29 antimicrobials from eight classes and applied it to 43 anonymous pig urine and muscle paired samples and fulfilled the parameters in agreement with the Commission Decision 2002/657/UE. The analytical limits were moreover much lower than the maximum residue limits (MRLs) required by the Commission Regulation 37/2010/UE. In the samples, antibiotics were usually detected at higher frequencies and concentrations in urine than muscle. Urine proved a useful tool to detect antibiotic administration and their excessive use in pig farming is depicted. (C) 2017 Published by Elsevier Ltd.
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