期刊
FOOD CHEMISTRY
卷 216, 期 -, 页码 19-26出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2016.07.141
关键词
Atopic dermatitis; Cacao; Immune cell infiltration; Inflammatory cytokines; Inflammatory skin lesions
资金
- Mid-career Researcher Program through the National Research Foundation (NRF) grant - Ministry of Education, Science and Technology (MEST), Republic of Korea [2015R1A2A1A10053567]
- Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET) through Agri-Bio industry Technology Development Program
- Ministry of Agriculture, Food and Rural Affairs (MAFRA), Republic of Korea [514004]
- Bio & Medical Technology Development Program of the National Research Foundation (the Civil research projects for solving social problems through the National Research Foundation of Korea (NRF)) - Ministry of Science, ICT & Future Planning [2013M3C8A2A01079268]
Cacao beans from Theobroma cacao are an abundant source of polyphenols, particularly flavonoids. Previous studies demonstrated that cacao flavanols decrease pro-inflammatory cytokines resulting in the alleviation of allergic symptoms. We sought to investigate the effects of cacao extract (CE) on Dermatophagoides farinae extract (DFE)-induced atopic dermatitis (AD)-like symptoms. CE attenuated DFE-induced AD-like symptoms as assessed by skin lesion analyses, dermatitis score, and skin thickness. Histopathological analysis revealed that CE suppressed DFE-induced immune cell infiltration into the skin. These observations occurred concomitantly with the downregulation of inflammatory markers including serum immunoglobulin (Ig) E, chemokine; thymus and activation-regulated chemokine and macrophage-derived chemokine as well as the skin-derived cytokines interleukin (IL)-4, IL-5, and interferon-gamma. CE also significantly alleviated transepidermal water loss and increased skin hydration. These results suggest that CE, a natural phytochemical-rich food, has potential therapeutic efficacy for the treatment of AD. (C) 2016 Published by Elsevier Ltd.
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