期刊
FOOD CHEMISTRY
卷 237, 期 -, 页码 803-810出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2017.06.019
关键词
Polyphenol; Oral bioavailability; In vitro release; Nutraceutic; Food enrichment; Supplement
资金
- European Union (FEDER funds)
- National Funds (FCT/MEC, Fundacao para a Ciencia e a Tecnologia and Ministerio da Educacao e Ciencia) [PT2020 UID/MULTI/04378/2013 - POCI/01/0145/FEDER/007728]
- FCT (Fundacao para a Ciencia e Tecnologia) from the International Doctoral Programme on Cellular and Molecular Biotechnology Applied to Health Sciences (BiotechHealth) [PD/BI/128352/2017]
- CNPq, Ministry of Education of Brazil [246514/2012-4]
- CAPES Foundation, Ministry of Education of Brazil [0831-12-3]
- FCT [IF/00293/2015]
- FCT
- POPH (Programa Operacional Potencial Humano) [SFRH/BPD/99124/2013]
- [NORTE-01-0145-FEDER-00001]
- Fundação para a Ciência e a Tecnologia [PD/BI/128352/2017] Funding Source: FCT
The well-known pleiotropic health benefits of green tea are mainly attributed to epigallocatechin-3-gallate (EGCG), a polyphenolic compound from the group of catechins. EGCG's poor stability and intestinal permeability, however, can strongly impair its biological activities. In this work, EGCG-loaded nanostructured lipid carriers (NLC) functionalized with folic acid were optimized through a Box-Behnken design intended to provide an enhanced oral absorption and increased bioavailability of EGCG. Size, zeta potential and encapsulation efficiency (EE) of the produced spherical nanoparticles were evaluated. NLC were further characterized by Differential Scanning Calorimetry (DSC). An in vitro release study in simulated gastric and intestinal fluids was conducted and the storage stability of the nanoparticles was evaluated over a period of 8 weeks. The overall results demonstrated the suitability of the developed formulation for the oral delivery of EGCG and its potential for applications in food industry. (C) 2017 Elsevier Ltd. All rights reserved.
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