Direct functionalization of cyclic ethers with maleimide iodides via free radial-mediated sp3 C-H activation

Cyclic ethers are important scaffolds employed in the synthesis of various natural products and pharmaceutical ingredients. A novel free radical-initiated reaction between cyclic ethers and maleimide iodides through C-H activation is developed, avoiding the use of transition metallic catalysts. This method provides a simple approach to derive cyclic ethers, which were further applied in various cross coupling reactions.

Automated summary

A novel free radical-initiated reaction between cyclic ethers and maleimide iodides through C-H activation has been developed, providing a simple approach to derive cyclic ethers without using transition metallic catalysts. These cyclic ethers can be further applied in various cross coupling reactions.