期刊
ORGANIC CHEMISTRY FRONTIERS
卷 8, 期 12, 页码 3008-3013出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1qo00232e
关键词
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资金
- Natural Science Foundation of Zhejiang Province (ZJNSF) [LY19B020005]
- Pandeng Plan Foundation of Hangzhou Normal University
A new method for the stereospecific cyanation of olefinic C-H bonds using rhodium catalysis has been developed, resulting in the synthesis of beta,beta-disubstituted acrylonitriles under mild conditions. This approach does not require directing groups, tolerates various functional groups, and provides a concise and green access to a wide range of disubstituted acrylonitriles in good to excellent yields.
Rhodium-catalyzed stereospecific cyanation of the olefinic C-H bond using environmentally benign N-cyano-N-phenyl-p-methylbenzenesulfonamide (NCTS) as a cyanating reagent for the synthesis of beta,beta-disubstituted acrylonitriles has been developed. The mechanism involves electrophilic cyanation of an alkenylrhodium intermediate which is generated in situ via 1,4-rhodium migration. This approach does not require directing groups, tolerates various functional groups, and provides a concise and green access to a wide range of disubstituted acrylonitriles in generally good to excellent yields under mild conditions.
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