期刊
CHEMICAL SCIENCE
卷 12, 期 19, 页码 6684-6690出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1sc01024g
关键词
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资金
- National Natural Science Foundation of China [21773240, 22001248]
- Fundamental Research Funds for the Central Universities
- University of the Chinese Academy of Sciences
The novel strategy for the selective synthesis of olefins presented in this study utilizes EDA complexes, eliminating the need for transition metal catalysts and photocatalysts. The method is operationally simple, straightforward, shows high regio- and stereoselectivities, and allows for the synthesis of olefins from easily available starting materials.
Olefins are prevalent substrates and functionalities. The synthesis of olefins from readily available starting materials such as alcohols, amines and carboxylic acids is of great significance to address the sustainability concerns in organic synthesis. Metallaphotoredox-catalyzed defunctionalizations were reported to achieve such transformations under mild conditions. However, all these valuable strategies require a transition metal catalyst, a ligand or an expensive photocatalyst, with the challenges of controlling the region- and stereoselectivities remaining. Herein, we present a fundamentally distinct strategy enabled by electron donor-acceptor (EDA) complexes, for the selective synthesis of olefins from these simple and easily available starting materials. The conversions took place via photoactivation of the EDA complexes of the activated substrates with alkali salts, followed by hydrogen atom elimination from in situ generated alkyl radicals. This method is operationally simple and straightforward and free of photocatalysts and transition-metals, and shows high regio- and stereoselectivities.
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