Electronic control of drug release from gauze or cellulose acetate fibres for dermal applications†

Electronic controlled drug release from fibres was studied using ibuprofen as a model drug, one of the most popular analgesics, to impregnate gauze and cellulose acetate (CA) membranes. Conductivity in the range of 1-10 mS cm(-1) was obtained in polypyrrole (Ppy) functionalised gauze and CA fibres, providing voltage-controlled drug release in a system consisting of Ppy/Ibuprofen/Ppy membranes and an Ag electrode. SEM images evidenced the Ppy adhesion to fibres and Micro Raman spectra proved drug incorporation and release. A small wound adhesive built with these membranes retains ibuprofen at 1.5 V and quickly releases it when -0.5 V is applied.

Automated summary

The study explored electronic controlled drug release from fibres using ibuprofen as a model drug, demonstrating voltage-controlled drug release with Ppy functionalised gauze and CA fibres. SEM images showed Ppy adhesion to fibres, while Micro Raman spectra confirmed drug incorporation and release. A small wound adhesive built with these membranes was able to retain ibuprofen at 1.5 V and quickly release it at -0.5 V.