A synergistic effect of hydrophobic deep eutectic solvents based on terpenoids and carboxylic acids for tetracycline microextraction

Hydrophobic deep eutectic solvents were investigated for tetracycline microextraction. It was found that a deep eutectic solvent consisting of thymol and octanoic acid provided a synergistic effect on tetracycline extraction. In this paper, a novel liquid-liquid microextraction procedure for the HPLC-DAD determination of tetracyclines in milk samples was proposed.

Automated summary

The study investigated the use of hydrophobic deep eutectic solvents for tetracycline microextraction, and found that a deep eutectic solvent composed of thymol and octanoic acid exhibited a synergistic effect on tetracycline extraction. A novel liquid-liquid microextraction procedure for the determination of tetracyclines in milk samples using HPLC-DAD was proposed in this research.