期刊
CELL REPORTS MEDICINE
卷 2, 期 3, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.xcrm.2021.100206
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资金
- Lions Forskningsfond mot folksjukdomar [Lions LiU-2019-03041]
- Swedish Research Council [921.2014-7060, 2016-01715_3]
- Swedish Society for Medical Research
- Swedish Society of Medicine
- Research Council for South-East Sweden
- Region Ostergotland
- BioGaia AB, Stockholm, Sweden
- Swedish National Infrastructure for Computing (SNIC) through Uppsala Multidisciplinary Center for Advanced Computational Science (UPPMAX) [SNIC 2020/5-336]
- The Ekhaga Foundation
- ALF
- Swedish Research Council [2016-01715] Funding Source: Swedish Research Council
Probiotics may exert benefits in modulating the gut microbiota composition during the first month in extremely low birth weight infants, leading to increased bacterial diversity and abundance of Lactobacillus reuteri, while reducing the abundance of certain harmful bacterial families.
Extremely low birth weight (ELBW) infants often develop an altered gut microbiota composition, which is related to clinical complications, such as necrotizing enterocolitis and sepsis. Probiotic supplementation may reduce these complications, and modulation of the gut microbiome is a potential mechanism underlying the probiotic effectiveness. In a randomized, double-blind, placebo-controlled trial, we assessed the effect of Lactobacillus reuteri supplementation, from birth to post-menstrual week (PMW)36, on infant gut microbiota. We performed 16S amplicon sequencing in 558 stool samples from 132 ELBW preterm infants at 1 week, 2 weeks, 3 weeks, 4 weeks, PMW36, and 2 years. Probiotic supplementation results in increased bacterial diversity and increased L. reuteri abundance during the 1st month. At 1 week, probiotic supplementation also results in a lower abundance of Enterobacteriaceae and Staphylococcaceae. No effects were found at 2 years. In conclusion, probiotics may exert benefits by modulating the gut microbiota composition during the 1st month in ELBW infants.
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