期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 105, 期 -, 页码 322-336出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2017.05.002
关键词
Doxorubicin; Oxidative impairment; Apoptosis; Liver injury; Ipomoea aquatica leaf extract; Antioxidants
资金
- Council for Scientific and Industrial Research, New Delhi, India (CSIR- SRF) [09/096(773)/2013-EMR-I]
- DBT, New Delhi, India [BT/RLF/Re-Entry/34/2013]
Ipomoea aquatica Forssk. (Convolvulaceae) is an aquatic vegetable traditionally employed against toxic effects of xenobiotics. The present study has been designed to investigate the molecular mechanism underlying the beneficial role of the edible (aqueous) leaf extract of I. aquatica (AEIA) against doxorubicin (Dox)-induced liver injury. AEIA exhibited a dose-dependent (similar to 400 mu g/ml) increase in cell viability against Dox (1 mu M) in isolated rodent hepatocytes. AEIA (400 mu g/ml) prevented the Dox-induced increase in ROS, redox imbalance, and activation of mitogen activated protein kinases (MAPK) and intrinsic pathway of apoptosis in hepatocytes. In the in vivo assay, administration of AEIA (100 mg/kg, p.o.) against Dox (3 mg/kg, i.p.) also reduced the oxidative impairment DNA fragmentation, ATP formation, and up regulated the mitochondrial co-enzymes Qs in the liver tissues of Wistar rats. Histological assessments were in agreement with the biochemical findings. Substantial quantities of phyto-antioxidants in AEIA may mediate its beneficial function against Dox-induced liver injury. (C) 2017 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据