期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 109, 期 -, 页码 505-516出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2017.09.050
关键词
Lycopene; Cognitive impairment; Oxidative stress; Neuroinflammation; Nrf2/NF-kappa B transcriptional pathway
资金
- National Key Research and Development Program of China [2016YFD0400601]
- National Natural Science Foundation of China [31671859]
- General Financial Grant from the China Postdoctoral Science Foundation [2016M602867]
Oxidative stress, considered as a major culprit in brain aging, triggers cognitive and memory impairment. Lycopene (LYC), a carotenoid pigment, possesses potent antioxidative, anti-inflammatory, and neuroprotective properties. In the present study, the effects of LYC on oxidative stress-induced cognitive defects and the Underlying mechanisms were determined. The behavioral tests, including Y-maze test, locomotor activity and Morris water maze test, revealed that chronic LYC supplementation (50 mg/kg bodyweight per day) alleviated D-galactose induced CD-1 male mice cognitive impairments. LYC ameliorated histopathological damage and restored brain derived neurotrophic factor (BDNF) levels in the hippocampus of mice. LYC also significantly elevated antioxidant enzymes activities and reduced levels of inflammatory cytokines in the D-galactose-treated mice serum. Moreover, LYC treatment activated the mRNA expressions of antioxidant enzymes HO-1 and NQO-1, and downregulated inflammatory cytokines IL-1 beta and TNF-alpha in mice hippocampus. Immunohistochemical results also demonstrated that LYC significantly restored the expression of glial cells inflammatory makers Iba-1 and GFAP. Furthermore, LYC attenuated neuronal oxidative damage through activation of Nrf2 signaling and inactivation of NF-kappa B translocation in a H2O2-induced SH-SY5Y cell model. Therefore, these results illustrated that LYC could ameliorate oxidative stress induced neuroinflammation and cognitive impairment possibly via mediating Nrf2/NF-kappa B transcriptional pathway.
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