期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 108, 期 -, 页码 510-518出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2017.01.003
关键词
Hemimethyl-substituted cucurbit[7]uril; Macrocyclic molecule; Zebrafish; Toxicity
资金
- Science and Technology Development Fund [FDCT 020/2015/A1]
- Research Committee Fund at University of Macau [MYRG2016-00008-ICMS-QRCM]
Hemimethyl-substituted cucurbit[7]uril (HMeCB[7]), a derivative of cucurbit[7]uril (CB[7]) with nearly identical host guest complexation properties to that of the parent, has significant potential in biomedical sciences due to its superior solubility in water. Its toxicity profile has been investigated in this work, including its developmental and organ-specific toxicities, with both in vivo zebrafish models and a relevant in vitro cellular model. These results demonstrated that HMeCB[7] has negligible developmental toxicity at concentrations up to 3.2 mM and very moderate cardiotoxicity and hepatotoxicity at concentrations of >= 0.8 mM, and is thus generally less toxic than the parent CB[7]. Our results suggest that HMeCB[7] may be a promising candidate of excipient in medicinal and pharmaceutical research fields. (C) 2017 Elsevier Ltd. All rights reserved.
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