Single gold nanoparticle-driven heme cofactor nanozyme as an unprecedented oxidase mimetic

The catalytic diversity of heme enzymes is a perpetuating pursuit for biomimetic chemistry, but heme nanozymes exhibit catalytic activity only reminiscent of peroxidases. Miraculously, the oxidase-like catalytic function of a heme cofactor is elicited with the help of gold nanoparticles (AuNPs) by maintaining heme with a low-valence state (ferrous) in a confined configuration.

Automated summary

Heme nanozymes display catalytic activity similar to peroxidases, and with the help of gold nanoparticles, the heme cofactor can maintain a low-valence state to trigger oxidase-like catalytic function.