期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 101, 期 -, 页码 121-127出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2017.01.008
关键词
Diarrhetic shellfish poisoning; Okadaic acid; Dinophysis; Lipophilic toxins
资金
- European Community [311820]
- TOXMASS (Operational Fisheries Program - Promar)
- Portuguese Foundation for Science and Technology (FCT) [UID/Multi/04326/2013]
- Portuguese Science and Technology Foundation (FCT) [PD/BD/113484/2015]
- FCT Investigator program (IF)
- Fundação para a Ciência e a Tecnologia [PD/BD/113484/2015] Funding Source: FCT
Okadaic acid (OA), Dinophysistoxins (DTX1 and DTX2) and their acyl-derivatives (DTX3) are marine toxins responsible for the human diarrhetic shellfish poisoning. To date the amount of toxins ingested from consumption of shellfish has been considered equal to the amount of toxins available for uptake by the human body. The aim of this study is to assess the OA, DTX2 and DTX3 fractions released from raw and steamed mussels and cockles into the digestive fluids (bioaccessibility) using a static in vitro digestion model. Higher bioaccessibility was found in mussels (86 +/- 4%) than in cockles (59 +/- 9%). A significant reduction of ester derivatives of OA and an increase of OA were observed in the bioaccessible fraction of mussel samples, suggesting that DTX3 undergo conversion into their more toxic parent compounds during human digestion. However, similar increase of DTX2 and reduction of the respective acyl derivatives was not observed. Steaming lead to significant reduction of OA and analogues bioaccessibility in both species even though increased concentrations of toxins are obtained after this treatment. Risk assessment based solely on DSP toxins occurrence in seafood can conduct to an overestimation of the exposure and lead to more conservative regulatory measures. (C) 2017 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据