期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 106, 期 -, 页码 8-16出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2017.05.020
关键词
Polyphenols; Luteolin; Apigenin; Chrysoeriol; C-rhamnosyl flavones; Inflammation
资金
- National Funds (FCT/MEC, Fundacao para a Ciencia e Tecnologia/Ministerio da Educacao e Ciencia) [UID/QUI/50006/2013]
- European Union (FEDER)
- Norte Portugal Regional Operational Programme (NORTE), under the PORTUGAL Partnership Agreement, through the European Regional Development Fund (ERDF) [NORTE-01-0145-FEDER-000024]
- Graduate Program Scholarship from the Graduate School of Kasetsart University
Vitex spp. have been reported as constituents of herbal preparations, namely Vitex peduncularis, commonly used in Asian countries. Unlike other species extensively investigated, reports on the biological activities and chemical profile of V. peduncularis are still scarce. In this work, the polyphenolic profile of V. peduncularis stem bark was unveiled, revealing a high content of apigenin and luteolin derivatives. More than 20 polyphenols were identified and quantitated for the first time, including C-rhamnosyl flavones infrequently reported. Regarding potential anti-inflammatory properties, the methanolic extract of the stem bark significantly reduced the levels of NO in macrophages, which may be a consequence of scavenging effect upon (NO)-N-center dot. Significant inhibition of phospholipase A(2) activity was also noted. Consequently, the therapeutic applicability of this edible plant is also broadened due to the anti-inflammatory properties found. (C) 2017 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据