期刊
ACS APPLIED BIO MATERIALS
卷 4, 期 4, 页码 2941-2956出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.1c00051
关键词
angiogenesis; vascularization; tissue engineering; tissue scaffolds; in vitro/in vivo assays
资金
- project B-FABULUS - Portuguese Foundation for Science and Technology (FCT) [PTDC/BBB-ECT/2690/2014]
- European Regional Development Fund (FEDER)
- Operational Programme for Competitiveness and Internationalisation (POCI)
- H2020-MSCA-RISE BAMOS project - European Union's Horizon 2020 research and innovation program [734156]
- FCT [SFRH/BD/143954/2019, IF/00115/2015]
- project Fun4TE - Portuguese Foundation for Science and Technology (FCT) [PTDC/EMD-EMD/31367/2017]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/143954/2019, PTDC/BBB-ECT/2690/2014, PTDC/EMD-EMD/31367/2017] Funding Source: FCT
This review focuses on vascularization in tissue engineering, discussing the formation of vascular networks within scaffolds and their ability to connect to the patient's vasculature. It also explores the development of angiogenesis techniques and monitoring methods, and how these can be utilized to tailor vascularization in large tissue engineered constructs. Finally, it offers an outlook on vascularization and emerging bioprinting concepts in tissue engineering applications.
This review focuses on vascularization and strategies involved in its evaluation and modulation. Clinical issues associated with engineered tissues of an atomically relevant size that require a vascular network to supply their cells with nutrients and oxygen are analyzed in terms of vascular network formation within scaffolds, which can be produced from varying biomaterials, with the capability of connecting to the vasculature of the patient. Developing angiogenesis techniques and monitoring of angiogenesis development as well as how these methods can be further utilized to tailor vascularization within large tissue engineered constructs are also discussed. Finally, we offer a glimpse toward the future by providing an outlook for vascularization and associated emerging bioprinting concepts in tissue engineering applications.
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