期刊
CHEMICAL SCIENCE
卷 12, 期 23, 页码 8073-8078出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1sc00986a
关键词
-
资金
- DFG (Gottfried-Wilhelm-Leibniz award)
- CSC
The study reported a ruthenium-catalyzed meta-C-H deaminative alkylation using easily accessible amino acid-derived Katritzky pyridinium salts, as well as remote C-H benzylations with high levels of chemoselectivity and remarkable functional group tolerance. This method, combining meta-C-H activation with deaminative strategy, represents a rare example of selectively converting C(sp(3))-N bonds into C(sp(3))-C(sp(2)) bonds.
Precise structural modifications of amino acids are of importance to tune biological properties or modify therapeutical capabilities relevant to drug discovery. Herein, we report a ruthenium-catalyzed meta-C-H deaminative alkylation with easily accessible amino acid-derived Katritzky pyridinium salts. Likewise, remote C-H benzylations were accomplished with high levels of chemoselectivity and remarkable functional group tolerance. The meta-C-H activation approach combined with our deaminative strategy represents a rare example of selectively converting C(sp(3))-N bonds into C(sp(3))-C(sp(2)) bonds.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据