期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 19, 期 19, 页码 4193-4212出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ob00409c
关键词
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资金
- Science and Engineering Research Board (SERB)-DST [SRG/2019/000117, SG0002]
- UGC-India
The imine umpolung strategy has shown significant progress in catalytic asymmetric synthesis. Chiral catalysts are used to generate 2-azaallyl anion intermediates, driving the umpolung addition/substitution reactions and achieving an excellent level of asymmetric induction. This approach has successfully been applied to the synthesis of amino-acid derivatives and other useful chiral amines, including drugs and potentially bioactive molecules.
The imine umpolung is a relatively new and interesting strategy, especially in catalytic asymmetric synthesis. A significant development in organo- and transition metal-catalyzed umpolung of imines took place only in the recently concluded decade. A majority of the reports on the asymmetric umpolung of imines involve the initial generation of 2-azaallyl anion intermediates with the chiral catalysts, which serve as a significant driving force for the umpolung addition/substitution reactions. A variety of organocatalysts such as bifunctional cinchona alkaloids including squaramides and thioureas, chiral BINOL derived phosphoric acids, phase transfer catalysts (PTCs), phosphines, and transition metal-complexes of iridium, copper and palladium have been employed to achieve the excellent level of asymmetric induction in such types of umpolung reactions. The asymmetric imine umpolung strategy has been applied successfully to synthesize synthetic amino-acid derivatives and other useful chiral amines, including drugs and potentially bioactive molecules. This review summarizes all the significant recent development in catalytic umpolung reactions of imines involving a 2-azaallyl anion intermediate.
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