Bacille Calmette-Guerin Vaccine-induced Osteomyelitis in Immunocompetent Children A 10-year Case Series in Lithuania

The Bacille Calmette-Guerin (BCG)-induced osteomyelitis is an extremely rare systemic adverse reaction after BCG vaccination in immunocompetent children and the correct diagnosis is frequently missed. We present 4 clinical cases of BCG-induced osteomyelitis reported over a 10-year period in a high-TB incidence country Lithuania. A brief review of clinical, management and treatment features of the disease is given.

Automated summary

BCG-induced osteomyelitis is an extremely rare systemic adverse reaction in immunocompetent children after BCG vaccination, with correct diagnosis frequently missed. This article presented 4 clinical cases reported over a 10-year period in Lithuania, a high TB incidence country, and briefly reviewed the clinical, management, and treatment features of the disease.