Enantioselective synthesis of functionalized 1,4-dihydropyrazolo-[4′,3′:5,6]pyrano[2,3-b]quinolines through ferrocenyl-phosphine-catalyzed annulation of modified MBH carbonates and pyrazolones

An enantioselective synthesis of highly functionalized 1,4-dihydropyrazolo[4 ',3 ':5,6]pyrano[2,3-b]quinolines from modified MBH carbonates and pyrazolones via a chiral phosphine-mediated alkylation/annulation sequence has been realized. The chiral dihydropyrano[2,3-c]pyrazoles bearing bio-active condensed heterocycles were facilely formed in good chemical yields and with high to excellent enantioselectivity by utilizing low catalyst loading.

Automated summary

This study demonstrates an enantioselective synthesis of highly functionalized compounds using a chiral phosphine-mediated alkylation/annulation sequence, resulting in good chemical yields and excellent enantioselectivity.