期刊
NEW JOURNAL OF CHEMISTRY
卷 45, 期 17, 页码 7893-7899出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0nj06289h
关键词
-
资金
- ``Double First-Class'' University Project [CPU2018GY25]
In this study, a new drug delivery system composed of gold nanorods has been developed for near-infrared light activation, utilizing photothermal heating effect and thermo responsive volume transition for controlled drug release with real-time color indication.
Particle-based delivery systems have emerged as a powerful platform in controlled drug release. In the present study, we developed a new inverse opal hydrogel microcarrier system composed of gold nanorods (AuNRs) for near-infrared light (NIR) activated drug delivery. AuNRs with a desired aspect ratio were prepared by a seed-mediated growth method. The inverse opal hydrogel microcarriers composited with AuNRs were synthesized by negatively replicating silica colloidal crystal beads (SCCBs). The NIR-thermo response of the microcarriers was due to the NIR photothermal heating effect of AuNRs and the thermo responsive volume transition of poly(N-isopropylacrylamide) (pNIPAM) hydrogel. It was found that the NIR-controlled reversible shrinking response of the microcarriers was ideal for the controllable drug release with real-time self-reporting color indication.
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