4.6 Article

An oral biologics carrier from modified halloysite nanotubes

期刊

NEW JOURNAL OF CHEMISTRY
卷 45, 期 20, 页码 9130-9136

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1nj00093d

关键词

-

资金

  1. Kasetsart University Research and Development Institute [KURDI D47.60, KURDI D7.3.62, KURDI FF(KU) 17.64]
  2. Postdoctoral Fellowship from Kasetsart University
  3. PERCH-CIC

向作者/读者索取更多资源

The study investigated the use of halloysite nanotubes as a biologic nanocarrier, showing that modified HNTs are suitable for biologic delivery and leading to a significant boost in immune response in aquatic animals when biologics-loaded HNTs were administered.
The development of biologic delivery systems for human and animal disease prevention and therapeutics has garnered considerable attention. Although several organic and inorganic materials have been utilized to dispense biological molecules, the carriers of biologics for economic aquatic animals are still limited. Herein, halloysite nanotubes (HNTs), an abundant natural nanoclay, were investigated as a biologic nanocarrier. The surface of the HNTs was modified with aminosilane, chitosan, or both to improve tissue compatibility. The effect of surface modification was also studied to delineate the biologic loading. The biologic releasing patterns of the biologic-HNTs were also observed through the acid-bile salt tolerance test, which mimics the harsh environment of the digestive system, the destination of the biologic-HNTs. The results demonstrated that the bare HNTs and modified HNTs displayed different loading biologic capacities. Similarly, the releasing properties of HNTs were different. Biologics-loaded HNTs were subsequently incorporated in the feed and given to Nile tilapia. A substantial boost of immune response was observed after a couple of weeks in all fish fed with biologics-loaded HNTs. These findings suggest that HNTs are suitable for oral biologic administration.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据