期刊
ORGANIC CHEMISTRY FRONTIERS
卷 8, 期 14, 页码 3990-4023出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1qo00481f
关键词
-
资金
- Chuo University personal research grant
This review summarizes recent examples of structure determination, correction, and disproof of structurally complex marine polyketide macrolides through chemical synthesis, highlighting the scope and limitation of current NMR-based structure analysis and the crucial role of chemical synthesis in structure elucidation.
Despite significant advances in NMR spectroscopy, structure elucidation of natural products, especially stereochemically complex polyketides with limited availability, is still a challenging task for chemists. Recent examples of structure determination, correction and disproof of structurally complex marine polyketide macrolides by chemical synthesis, namely lobatamide C, reidispongiolide A, callyspongiolide, palmerolide A, muironolide A, iriomoteolide-2a, and chagosensine cases, are summarized in this review, which highlights the scope and limitation of current NMR-based structure analysis and the vital role of chemical synthesis in structure elucidation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据