期刊
FITOTERAPIA
卷 122, 期 -, 页码 115-118出版社
ELSEVIER
DOI: 10.1016/j.fitote.2017.08.012
关键词
Isocoumarin; Pestalotiopsis sp.; Polyketide pathway; Antifimgal activity
资金
- National Natural Science Foundation of China [81503218]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT_1193]
- Priority Academic Program Development of Jiangsu higher Education Institutions (PAPD)
- Fundamental Research Funds for the Central Universities [2016ZZD010]
Five new isocoumarin derivatives, pestalactone A-C (1-3) and pestapyrone D-E (4-5), together with two known compounds (6-7) were isolated from the solid cultures of the endophytic fungus Pestalotiopsis sp. obtained from Photinia frasery. Their structures were mainly determined by extensive spectroscopic analysis, Mo-2(OCOCH3)4induced electronic circular dichroism (ECD), and ECD calculation. Compounds 1 and 2 were rare isocoumarin derivatives and derived from distinctive polyketide pathways. Compound 3 exhibited potent antifungal activity against Candida glabrata (ATCC 90030) with an MIC50 value of 3.49 +/- 0.21 mu g/mL.
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