期刊
FITOTERAPIA
卷 122, 期 -, 页码 126-131出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2017.09.007
关键词
TRP channels; TRPA1; TRPM8; TRPV1; Curctunin; Curcuminoids
资金
- Sapienza Universita di Roma [RG116154CF287B95]
A series of 33 curcumin analogues was synthesized and tested on TRPA1, TRPM8, and TRPV1 channels. Twenty of them acted as good modulators of TRPA1 channels. None was able to significantly activate TRPM8 channels, while curcumin itself and six curcuminoids belonging to the 1,3-dicarbonyl and acyclic series behaved as 'true' antagonists with IC50 values < 5 mu M. Only few curcuminoids were able to modulate TRPV1 channels with EC50 and IC50 values ranging from 3.4 and 6.0 mu M.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据