Anti-inflammatory lignanamides and monoindoles from Alocasia macrorrhiza

Five new lignanamides (1-5), and one new monoindole alkaloid (6), along With eight known compounds (7-14) were isolated and identified from the rhizomes of Alocasia macrorrhiza (giant taro). All purified compounds were evaluated for their inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 cells, and the antiproliferative activities against human nasopharyngeal carcinoma epithelial (CNE-1), human gastric carcinoma (MGC-803), and human breast cancer (MCF-7) cell lines by MIT method. Compounds 2, 4, 7 and 8 exhibited significant inhibitory effects on NO production with the IC50 values of 2.35 +/- 038, 9.20 +/- 0.94, 3.45 +/- 0.39 and 7.96 +/- 0.56 M, respectively. The results suggested the lignanamides and monoindoles might be responsible for the anti-inflammatory activity of giant taro and might be potential anti-inflammatory candidates. (C) 2016 Published by Elsevier B.V.