期刊
FITOTERAPIA
卷 119, 期 -, 页码 136-149出版社
ELSEVIER
DOI: 10.1016/j.fitote.2017.05.001
关键词
Quinazolinones; Chemical structures; Pharmaceutical activities; Structure-activity relationship
资金
- National Science Foundation of China [81573569, 81470177, 81001623, 81373773]
- Beijing Nova Program [xx2014B073]
- Beijing Natural Science Foundation [7142144]
Quinazolinones belong to a family of heterocyclic nitrogen compounds that have attracted increasing interest because of their broad spectrum of biological functions. This review describes three types of natural quinazolinones and their synthesized derivatives and summarizes their various pharmacological activities, including antifungal, anti-tumor, anti-malaria, anticonvulsant, anti-microbial, anti-inflammatory and antihyperlipidemic activities. In addition, structure-activity relationships of quinazolinone derivatives are also reviewed.
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