期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 9, 期 19, 页码 4015-4023出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1tb00425e
关键词
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资金
- Basic Science Research Program through the National Research Foundation (NRF) of Korea - Ministry of Education [NRF-2018-R1A6A1A03025124, NRF-2018-R1D1A1B07043383]
- Ministry of Science ICT and Future Planning [NRF-2020-R1A2C2013790, NRF-2019-M3E6A1065038]
- Bio & Medical Technology Development Program of the NRF of Korea [NRF-2019-M3A9H1103783]
- Korea Basic Science Institute (National Research Facilities and Equipment Center) - Ministry of Education [NRF-2020-R1A6C101A184]
- NRF - Korean government [NRF-2017-R1C1B3009321]
This study reveals the tumor alleviation properties of a nanozyme consisting of amine-terminated sixth-generation polyamidoamine dendrimers encapsulated with tiny platinum nanoparticles, showing potential for application in GBM-related basic research and clinical settings. By suppressing GBM cell migration, invasion, and adhesion, the nanozyme demonstrates its ability for tumor alleviation.
Nanozymes are nanostructure-based materials which mimic the enzymatic characteristics of natural enzymes. Biological applications of nanozymes have been highlighted in basic research, industry, and translational medicine as a new cutting-edge tool. In this work, and for the first time, we disclose a tumor alleviation property of a nanozyme that is made up of amine-terminated sixth-generation polyamidoamine dendrimers with encapsulated tiny platinum nanoparticles. We systematically conducted the synthesis and characterization of the dendrimer-encapsulated Pt nanoparticles (denoted Pt-dendrimer) and confirmed their enzymatic function (hydrogen peroxide (H2O2) decomposition) within various cell lines (normal, cancerous), including glioblastoma (GBM) cells. By understanding the effects of the Pt-dendrimer at the gene level, especially related to cancer cell metastasis, we have thoroughly demonstrated its ability for tumor alleviation and suppressing GBM migration, invasion, and adhesion. The present findings show great promise for the application of the nanozyme for use in GBM-related basic research as well as at clinical sites.
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