期刊
TRANSLATIONAL SPORTS MEDICINE
卷 4, 期 2, 页码 174-192出版社
WILEY
DOI: 10.1002/tsm2.215
关键词
fitness; high-throughput sequencing; human microbiome; longitudinal study; metabolic phenotyping; n of 1
资金
- Science Foundation Ireland [11/PI/1137, 13/SIRG/2160]
- APC Microbiome Institute [SFI/12/RC/2273]
- Department of Agriculture, Food, and Marine on behalf of the government of Ireland [16/RC/3835]
- NIHR [NIHR-CDF-2017-10-032]
- Science Foundation Ireland (SFI) [13/SIRG/2160, 11/PI/1137] Funding Source: Science Foundation Ireland (SFI)
The study showed that sustained fitness improvement significantly affects the gut microbiome and metabolites, increasing diversity and causing fluctuations during training events. Through experiments, it was found that fitness training has a significant impact on the gut microbiome and can improve overall physical health.
The athlete gut microbiome differs from that of non-athletes in its composition and metabolic function. Short-term fitness improvement in sedentary adults does not replicate the microbiome characteristics of athletes. The objective of this study was to investigate whether sustained fitness improvement leads to pronounced alterations in the gut microbiome. This was achieved using a repeated-measures, case-study approach that examined the gut microbiome of two initially unfit volunteers undertaking progressive exercise training over a 6-month period. Samples were collected every two weeks, and microbiome, metabolome, diet, body composition, and cardiorespiratory fitness data were recorded. Training culminated in both participants completing their respective goals (a marathon or Olympic-distance triathlon) with improved body composition and fitness parameters. Increases in gut microbiota alpha -diversity occurred with sustained training and fluctuations occurred in response to training events (eg, injury, illness, and training peaks). Participants' BMI reduced during the study and was significantly associated with increased urinary measurements of N-methyl nicotinate and hippurate, and decreased phenylacetylglutamine. These results suggest that sustained fitness improvements support alterations to gut microbiota and physiologically-relevant metabolites. This study provides longitudinal analysis of the gut microbiome response to real-world events during progressive fitness training, including intercurrent illness and injury.
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