Time-programmable pH: decarboxylation of nitroacetic acid allows the time-controlled rising of pH to a definite value

In this report it is shown that nitroacetic acid 1 (O2NCH2CO2H) can be conveniently used to control the pH of a water solution over time. Time-programmable sequences of the kind pH(1(high))-pH(2(low))-pH(3(high)) can be achieved, where both the extent of the initial pH jump (pH(1(high))-pH(2(low))) and the time required for the subsequent pH rising (pH(2(low))-pH(3(high))) can be predictably controlled by a judicious choice of the absolute and relative concentrations of the reagents (acid 1 and NaOH). Successive pH(1(high))-pH(2(low))-pH(3(high)) sequences can be obtained by subsequent additions of acid 1. As a proof of concept, the method is applied to control over time the pH-dependent host-guest interaction between alpha-cyclodextrin and p-aminobenzoic acid.

Automated summary

The report demonstrates the use of nitroacetic acid to control the pH of a water solution over time, allowing for time-programmable pH sequences by predicting the extent of pH changes and time required through reagent concentrations. The method was successfully applied to control the pH-dependent host-guest interaction.