期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 9, 期 21, 页码 4267-4286出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0tb02713h
关键词
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资金
- Ministry of Science and Technology of Taiwan [MOST 108-2113-M-007-019-/109-2113M-007-014-]
- National Tsing Hua University
- Chang Gung Memorial Hospital, Taiwan [CORPG3I0021/CORPG3K0041]
Magnetic nanoparticles (MNPs) are gaining increasing attention for enhancing gene delivery efficiency, as well as for their applications in magnetic resonance imaging and magnetic hyperthermia therapy. Integrating MNPs with viral or nonviral gene vectors shows great potential in biomedical applications, including cutting-edge research technologies such as biomimetic cell membrane nano-gene carriers and CRISPR/Cas9 gene editing.
Gene delivery is an indispensable technique for various biomedical applications such as gene therapy, stem cell engineering and gene editing. Recently, magnetic nanoparticles (MNPs) have received increasing attention for their use in promoting gene delivery efficiency. Under magnetic attraction, gene delivery efficiency using viral or nonviral gene carriers could be universally enhanced. Besides, magnetic nanoparticles could be utilized in magnetic resonance imaging or magnetic hyperthermia therapy, providing extra theranostic opportunities. In this review, recent research integrating MNPs with a viral or nonviral gene vector is summarized from both technical and application perspectives. Applications of MNPs in cutting-edge research technologies, such as biomimetic cell membrane nano-gene carriers, exosome-based gene delivery, cell-based drug delivery systems or CRISPR/Cas9 gene editing, are also discussed.
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