期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 26, 期 4, 页码 771-796出版社
IMR PRESS
DOI: 10.2741/4917
关键词
miRNA; TLR; Immunity; Cytokine; SNAP; Chemokine; Review
资金
- National Institutes of Health [1SC3GM113751, U54 MD007602, G12-MD007602]
- NIH/NCRR [C06 RR018386]
Toll-like receptors (TLRs) are molecules that recognize molecular patterns and regulate the immune system, sustained immune activation can disrupt immune homeostasis leading to inflammatory diseases. MicroRNAs (miRNAs) can affect the immune regulatory network by regulating the expression of TLRs and TLR signaling components.
Toll-like receptors (TLRs) are evolutionarily conserved molecules that detect exogenous and endogenous molecular patterns and trigger both the innate and adaptive immune systems to initiate a pathogen-specific immune response and eliminate the threat. However, sustained, or prolonged activation of the immune system disrupts immunological homeostasis and leads to chronic or acute inflammatory diseases. MicroRNAs (miRNAs) can intervene in the initiation and modulation of the complex immunoregulatory networks via regulating the expression of TLRs and multiple components of TLR-signaling pathways including signaling proteins, transcription factors, and cytokines. Moreover, the aberrant expression of TLRs can induce the expression of several miRNAs which in turn regulate the expression of TLR signaling components and TLR-induced cytokines. The present review aims to highlight the emerging roles of miRNA in the regulation of TLR signaling, the interaction between the miRNAs and TLRs, and their implication in inflammatory diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据