4.2 Article

Graphene Oxide/Zinc Oxide Nanocomposite Displaying Selective Toxicity to Glioblastoma Cell Lines

期刊

ACS APPLIED BIO MATERIALS
卷 4, 期 1, 页码 829-843

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acsabm.0c01369

关键词

Glioblastoma; glioma; nanocarriers; nanoparticles; graphene oxide; zinc oxide; photothermal therapy

资金

  1. Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
  2. Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
  3. Fundacao de Apoio a Pesquisa no Distrito Federal (FAPDF)
  4. Fundacao de Empreendimentos Cientificos e Tecnologicos (FINATEC)
  5. Financiadora de Estudos e Projetos (FINEP)

向作者/读者索取更多资源

An innovative nanocomposite material GOC-ZnO-P has been proposed for chemotherapy against glioblastoma. This composite material demonstrates selectivity towards tumor cells and induces cell death through pathways of apoptosis.
Glioblastoma is considered the most aggressive and prevalent type of glioma. Resistance mechanisms, side effects, and the blood-brain barrier are factors that make its treatment difficult, requiring the development of alternative therapeutic strategies. Herein, we propose a nanocomposite composed of carboxylated graphene oxide nanosheets decorated with zinc oxide nanoparticles and post-functionalized with Pluronic (GOC-ZnO-P) for chemotherapy against U87MG and U138MG human glioblastoma cell lines. The GOC-ZnO-P formulation is fairly stable in the physiological medium (DMEM-FBS) and demonstrates selectivity toward tumor cell lines, even though it is less cytotoxic than free ZnO. Whereas the photothermal activity of the nanocomposite has a negligible cytotoxic effect, images obtained by scanning and transmission electron microscopies reveal that it induces changes in adhesion points and roughness of the tumor cell membrane, and it is uptaken through vesicles and capable of accumulating in the nudeus, a process that can induce cell death by apoptosis, as verified by flow cytometry. In summary, the GOC phase serves as an inert platform for transporting ZnO, which maintains its selectivity for tumor cells and does not interfere with the mechanisms for inducing apoptotic pathways. Therefore, the GOC-ZnO-P nanocomposite offers a strategy for glioblastoma treatment.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.2
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据