期刊
ACS APPLIED BIO MATERIALS
卷 4, 期 1, 页码 277-294出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.0c01328
关键词
nanoparticles; cancer immunotherapy; tumor oxygenation; hypoxia; immunosuppression
资金
- National Natural Science Foundation of China [21675167, 21775157, 22022410, 82050005]
- Shanghai Municipal Science and Technology Commission [19142202400, 19JC1410300]
- Youth Innovation Promotion Association of CAS [2016236]
Nanomaterial systems show promise in tumor oxygenation, reversing hypoxia-associated immunosuppression, enhancing immune responses, and effectively clearing metastatic cancer cells.
Cancer immunotherapy, which initiates or strengthens innate immune responses to attack cancer cells, has shown great promise in cancer treatment. However, low immune response impacted by immunosuppressive tumor microenvironment (TME) remains a key challenge, which has been found related to tumor hypoxia. Recently, nanomaterial systems are proving to be excellent platforms for tumor oxygenation, which can reverse hypoxia-associated immunosuppression, strengthen the systemic antitumor immune responses, and thus afford a striking abscopal effect to clear metastatic cancer cells. In this review, we would like to survey recent progress in utilizing nanomaterials for tumor oxygenation through approaches such as in situ O-2 generation, O-2 delivery, tumor vasculature normalization, and mitochondrial-respiration inhibition. Their effects on tumor hypoxia-associated immunosuppression are highlighted. We also discuss the ongoing challenges and how to further improve the clinical prospect of cancer immunotherapy.
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