期刊
SIGNAL TRANSDUCTION AND TARGETED THERAPY
卷 6, 期 1, 页码 -出版社
SPRINGERNATURE
DOI: 10.1038/s41392-021-00618-z
关键词
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资金
- CAMS Initiative for Innovative Medicine of China [2020-I2M-CoV19-009, 2016-I2M-2-006, 2018-I2M-1-003]
- National Natural Science Foundation of China [82041035]
- National Research and Development Project of China [2020YFC0841100]
- National Mega projects of China for Major Infectious Diseases [2017ZX10304402, 2018ZX10301403]
- National Key Research and Development Project of China [2016YFD0500304]
- Fundamental Research Funds for the Central Public Welfare Research Institutes [ZZ13-035-03]
The study found that co-infection with H1N1 and SARS-CoV-2 extended the duration of COVID-19 symptoms, enhanced lung damage, but reduced viral shedding. Mortality was also increased in sequentially infected mice. Co-inoculation of PiCoVacc and the flu vaccine showed no significant differences in neutralizing antibody titers or virus-specific immune responses.
Influenza A virus may circulate simultaneously with the SARS-CoV-2 virus, leading to more serious respiratory diseases during this winter. However, the influence of these viruses on disease outcome when both influenza A and SARS-CoV-2 are present in the host remains unclear. Using a mammalian model, sequential infection was performed in ferrets and in K18-hACE2 mice, with SARS-CoV-2 infection following H1N1. We found that co-infection with H1N1 and SARS-CoV-2 extended the duration of clinical manifestation of COVID-19, and enhanced pulmonary damage, but reduced viral shedding of throat swabs and viral loads in the lungs of ferrets. Moreover, mortality was increased in sequentially infected mice compared with single-infection mice. Compared with single-vaccine inoculation, co-inoculation of PiCoVacc (a SARS-CoV-2 vaccine) and the flu vaccine showed no significant differences in neutralizing antibody titers or virus-specific immune responses. Combined immunization effectively protected K18-hACE2 mice against both H1N1 and SARS-CoV-2 infection. Our findings indicated the development of systematic models of co-infection of H1N1 and SARS-CoV-2, which together notably enhanced pneumonia in ferrets and mice, as well as demonstrated that simultaneous vaccination against H1N1 and SARS-CoV-2 may be an effective prevention strategy for the coming winter.
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