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In silico and in vitro validation of serine hydroxymethyltransferase as a chemotherapeutic target of the antifolate drug pemetrexed
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Mammalian MTHFD2L Encodes a Mitochondrial Methylenetetrahydrofolate Dehydrogenase Isozyme Expressed in Adult Tissues
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JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Tetrahydrofolate Recognition by the Mitochondrial Folate Transporter
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Identification of miR-193b Targets in Breast Cancer Cells and Systems Biological Analysis of Their Functional Impact
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MOLECULAR & CELLULAR PROTEOMICS (2011)
Mthfs is an Essential Gene in Mice and a Component of the Purinosome
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Frontiers in Genetics (2011)
Pemetrexed Indirectly Activates the Metabolic Kinase AMPK in Human Carcinomas
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Farletuzumab, a Humanized Monoclonal Antibody against Folate Receptor α, in Epithelial Ovarian Cancer: a Phase I Study
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CLINICAL CANCER RESEARCH (2010)
Therapeutics by Cytotoxic Metabolite Accumulation: Pemetrexed Causes ZMP Accumulation, AMPK Activation, and Mammalian Target of Rapamycin Inhibition
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CANCER RESEARCH (2009)
Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia
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Folic acid metabolism in human subjects revisited: potential implications for proposed mandatory folic acid fortification in the UK
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Cholinergic precursors in the treatment of cognitive impairment of vascular origin: Ineffective approaches or need for re-evaluation?
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Inhibition of 5,10-methenyltetrahydrofolate synthetase
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ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2007)
Enzyme inhibitors from marine invertebrates
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Synthesis, dihydrofolate reductase inhibition, antitumor testing, and molecular modeling study of some new 4(3H)-quinazolinone analogs
Sarah T. Al-Rashood et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2006)
Targeting the α-folate receptor with cyclopenta[g]quinazoline-based inhibitors of thymidylate synthase
Elisa A. Henderson et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2006)
S-alkylated homocysteine derivatives:: New inhibitors of human betaine-homocysteine S-methyltransferase
Jiri Jiracek et al.
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Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase
Jessica K. DeMartino et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
BGC 945, a novel tumor-selective thymidylate synthase inhibitor targeted to α-folate receptor-overexpressing tumors
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CANCER RESEARCH (2005)
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Lipophilic antifolate trimetrexate is a potent inhibitor of Trypanosoma cruzi:: Prospect for chemotherapy of Chagas' disease
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ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2005)
Phase I study of OSI-7904L, a novel liposomal thymidylate synthase inhibitor in patients with refractory solid tumors
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CLINICAL CANCER RESEARCH (2005)
Inhibition of S-adenosyl-L-homocysteine hydrolase induces immunosuppression
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Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates
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Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid
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Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase
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Design and synthesis of cyclopenta[g]quinazoline-based antifolates as inhibitors of thymidylate synthase and potential antitumor agents
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Phase I study of AG2034, a targeted GARFT inhibitor, administered once every 3 weeks
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