期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 19, 期 21, 页码 4783-4787出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ob00562f
关键词
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资金
- Guangdong Basic and Applied Basic Research Foundation [2019A1515110866, 2019A1515110522]
- Department of Education of Guangdong Province [2019KZDXM052]
- Science Foundation for Young Teachers of Wuyi University [2019td06]
- Climbing Program Special Funds [pdjh2020a0596]
A simple and practical method for alpha-ketoamide synthesis via a decarboxylative strategy of isocyanates with alpha-oxocarboxylic acids has been described. The reaction proceeds at room temperature under mild conditions without the need for an oxidant or an additive, showing good substrate scope and functional compatibility. The applicability of this method was further demonstrated by the synthesis of various bioactive molecules and different application examples through a two-step one-pot operation.
A simple and practical method for alpha-ketoamide synthesis via a decarboxylative strategy of isocyanates with alpha-oxocarboxylic acids is described. The reaction proceeds at room temperature under mild conditions without an oxidant or an additive, showing good substrate scope and functional compatibility. Moreover, the applicability of this method was further demonstrated by the synthesis of various bioactive molecules and different application examples through a two-step one-pot operation.
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