Gut microbiota mediated the protective effects of tuna oil on collagen-induced arthritis in mice

Rheumatoid arthritis is emerging as a chronic autoimmune disease worldwide. In this study, the beneficial effects of tuna oil (TO) on collagen-induced arthritis (CIA) mice were investigated. Dietary administration of TO relieved arthritis severity and joint bone erosion, and ameliorated systemic inflammation. Furthermore, TO treatments regulated the phosphorylation of nuclear factor-kappa B (NF-kappa B) and Wnt1/beta-catenin signaling pathways in the joint, enhanced osteoblastogenesis biomarkers and suppressed osteoclastogenesis biomarkers, and subsequently re-balanced bone remodeling. Moreover, the impaired intestinal epithelial barrier was repaired after TO treatments, along with gut microbiota modulation. By employing fecal microbiota transplantation, we clarified that the beneficial effects of TO in CIA alleviation were mediated by the modulated gut microbiota. These results indicated that gut microbiota mediated the protective effects of tuna oil on collagen-induced arthritis in mice.

Automated summary

The study revealed that tuna oil has beneficial effects on collagen-induced arthritis in mice by reducing arthritis severity, improving joint bone erosion and systemic inflammation, balancing bone remodeling through signaling pathways, and repairing the impaired intestinal epithelial barrier and modulating gut microbiota.