期刊
FISH & SHELLFISH IMMUNOLOGY
卷 70, 期 -, 页码 228-239出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fsi.2017.08.029
关键词
Larimichthys crocea; Large yellow croaker; Chemokine receptor; CXCR family; Bacterial challenge; Marine fish
资金
- Open Project Program of the Key Laboratory of Mariculture & Enhancement of Zhejiang Province [2016KF003]
- Key Project of Zhejiang Province [2016C02055-7]
- International Science & Technology Cooperation Program of China [2015DFR30450]
The large yellow croaker (Larimichthys crocea) has a well-developed innate immune system. We studied a component of this system, chemokine receptor CXCR family. In this study, we report the full-length open reading frames, as well as the identification and characterization of the chemokine receptor genes CXCR2 (LycCXCR2), CXCR3 (LycCXCR3), and CXCR4 (LycCXCR4) of large yellow croaker. We report that LycCXCR3 and LycCXCR4 are evolving neutrally according to PAML analySes. Quantitative real-time PCR analysis revealed that CXCR transcripts were expressed in all examined tissues. The expression of chemokine receptors LycCXCR2, LycCXCR3, and LycCXCR4 was elevated in the kidney, spleen, and particularly the liver of the large yellow croaker after challenge with Vibrio anguillarum and polyinosinic:polycytidylic acid (poly I:C). These results suggest that LycCXCR2, LycCXCR3, and LycCXCR4 may be important immune related genes, playing crucial roles in immune defence against bacterial infection. (C) 2017 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据