期刊
ORGANIC CHEMISTRY FRONTIERS
卷 8, 期 14, 页码 3734-3739出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1qo00025j
关键词
-
资金
- National Natural Science Foundation of China [U2004189]
- Program for Innovative Research Team in Science and Technology in Universities of Henan Province [20IRTSTHN005]
- Key Project of Science and Technology of Henan Province [192102310412]
- 111 Project [D17007]
- NMPA Key Laboratory for Research and Evaluation of Innovative Drug
This paper presents a novel and efficient synthesis method for tetracyclic indenopyrazolopyrazolone derivatives through cascade reactions, demonstrating advantages of accessibility and potential pharmaceutical applications.
Presented herein is a novel and efficient synthesis of synthetically and biologically attractive tetracyclic indenopyrazolopyrazolone derivatives through the cascade reactions of aryl azomethine imines with propargyl alcohols. Mechanistically, the formation of the title products is believed to involve an initial inert C(sp(2))-H bond alkenylation followed by the cascade formation of two five-membered rings. To our knowledge, this is the first example in which propargyl alcohol acts as not only an alkenylation coupling partner but also a C2/C1 synthon to form indeno/pyrazolo scaffolds. Notable advantages of this novel protocol include easily accessible and moisture/air-stable substrates, high efficiency and excellent atom-economy. In addition, the cytotoxicity test of selected products against two human cancer cell lines demonstrated their potential for pharmaceutical applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据