期刊
CHEMICAL SCIENCE
卷 12, 期 13, 页码 4949-4957出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1sc00602a
关键词
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资金
- National Research Foundation of Korea [2018R1D1A1B07048527] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
A combination of supramolecular and covalent chemistry is used to create fullerene-containing polymer nanoparticles with a core-shell structure, overcoming the issue of poor water solubility.
Fullerenes have unique structural and electronic properties that make them attractive candidates for diagnostic, therapeutic, and theranostic applications. However, their poor water solubility remains a limiting factor in realizing their full biomedical potential. Here, we present an approach based on a combination of supramolecular and covalent chemistry to access well-defined fullerene-containing polymer nanoparticles with a core-shell structure. In this approach, solvophobic forces and aromatic interactions first come into play to afford a micellar structure with a poly(ethylene glycol) shell and a corannulene-based fullerene-rich core. Covalent stabilization of the supramolecular assembly then affords core-crosslinked polymer nanoparticles. The shell makes these nanoparticles biocompatible and allows them to be dried to a solid and redispersed in water without inducing interparticle aggregation. The core allows a high content of different fullerene types to be encapsulated. Finally, covalent stabilization endows nanostructures with stability against changing environmental conditions.
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