An iodine-mediated new avenue to sulfonylation employing N-hydroxy aryl sulfonamide as a sulfonylating agent

A novel and highly efficient I-2/K2CO3 mediated regioselective sulfonylation of thiophenols, aryl acetylenic acid and aromatic alkynes with N-hydroxy sulfonamide has been developed. N-hydroxy sulfonamide has been used for the first time for the synthesis of these sulfones. The scope and versatility of the reaction has been demonstrated by the regio- and stereoselective synthesis of different analogs of sulfones with various structural features.

Automated summary

A novel and highly efficient method using I-2/K2CO3 for the regioselective sulfonylation of thiophenols, aryl acetylenic acid and aromatic alkynes with N-hydroxy sulfonamide has been developed. The reaction demonstrates the versatility and scope by synthesizing different analogs of sulfones with various structural features.