4.4 Article

Gram-Scale Synthesis of Polymeric Carbon Nitride-Supported Copper: A Practical Catalyst for Ullmann-Type C-N Coupling Modifying Secondary Pyrimidin-2-amines without Additional Ligand

期刊

CHINESE JOURNAL OF ORGANIC CHEMISTRY
卷 41, 期 3, 页码 1216-1223

出版社

SCIENCE PRESS
DOI: 10.6023/cjoc202009014

关键词

polymeric carbon nitride (PCN); copper; catalysis; Ullmann-type C-N coupling reaction; pyrimidin-2-amine

资金

  1. Priority Academic Program Development of Jiangsu Higher Education Institutions

向作者/读者索取更多资源

Cu/polymeric carbon nitride (PCN) prepared by calcining Cu(NO3)(2) with the melamine precursor at 550 degrees C can catalyze the Ullmann-type C-N coupling reactions. The material is more active than traditional Cu(I) and Pd catalysts, offering an opportunity for developing efficient novel catalysts for synthesis of medicines containing pyrimidin-2-amine moieties.
Cu/polymeric carbon nitride (PCN) can be prepared in 10 g scale by calcining Cu(NO3)(2) with the melamine precursor at 550 degrees C. X-ray photoelectron spectroscopy (XPS) analysis demonstrated that copper in the material was in Cu(I) form and it could catalyze the Ullmann-type C-N coupling reactions of pyrimidin-2-amine derivatives with aryl halides without additional ligand. As a heterogeneous catalyst, the material was recoverable and could be reused for at least five times without deactivation. This material was found to be even more active than traditional Cu(I) catalysts and Pd catalysts, affording an opportunity to develop the efficient and practical novel catalyst reagent for the synthesis of medicines containing pyrimidin-2-amine moieties in pharmaceutical industry.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.4
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据