Application of Flow Chemistry in Halogenation

The halogenation of organic compounds is one of the most important transformations in organic synthesis. However, there are some problems in traditional batch halogenation, such as high exothermicity, poor selectivity and the use of highly toxic and corrosive halogenating agents. Flow chemistry has its unique advantages such as high mixing efficiency, fast heat and mass transfer performance, accurate control over process parameters and enhanced process safety, reduced energy input and so on. According to the classification of halogenation of organic compounds, the main progress of flow chemistry in fluorination, chlorination, bromination and iodization is summarized systematically, and its development trend is prospected.

Automated summary

The halogenation of organic compounds is a crucial transformation in organic synthesis, but traditional batch reactions face issues like high exothermicity. Flow chemistry offers unique advantages such as high mixing efficiency and enhanced process safety. Systematic summaries of flow chemistry progress in fluorination, chlorination, bromination and iodization have been made, with prospects for future development.