4.6 Review

Light therapy: a new option for neurodegenerative diseases

期刊

CHINESE MEDICAL JOURNAL
卷 134, 期 6, 页码 634-645

出版社

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/CM9.0000000000001301

关键词

Neurodegenerative diseases; Light therapy; Circadian rhythm

资金

  1. National Natural Science Foundation of China [81908217, 81801253, 91649114]
  2. Natural Science foundation of JiangsuHigher Education Institutions of China [19KJB180007]
  3. Jiangsu Provincial Social Development Projects [BE2018658, BE2017653]
  4. Jiangsu Provincial Medical Key Discipline Project [ZDXKB2016022]
  5. Jiangsu Province Postgraduate-Training Innovation Project [KYCX18_2545]
  6. Suzhou Clinical Research Center of Neurological Disease [Szzx201503]
  7. Priority Academic Program Development of Jiangsu Higher Education Institutions

向作者/读者索取更多资源

Light therapy (LT) has shown potential as a safe and convenient physical treatment method for patients with neurodegenerative disease. While some studies have reported limited or no effects, LT remains an attractive therapeutic approach for further investigation in ND. Further research through animal experiments and large clinical trials is needed to fully understand its mechanisms of action and true efficacy.
Given the increasing incidence of neurodegenerative disease (ND), recent research efforts have intensified the search for curative treatments. Despite significant research, however, existing therapeutic options for ND can only slow down the progression of the disease, but not provide a cure. Light therapy (LT) has been used to treat some mental and sleep disorders. This review illustrates recent studies of the use of LT in patients with ND and highlights its potential for clinical applications. The literature was collected from PubMed through June 2020. Selected studies were primarily English articles or articles that could be obtained with English abstracts and Chinese main text. Articles were not limited by type. Additional potential publications were also identified from the bibliographies of identified articles and the authors' reference libraries. The identified literature suggests that LT is a safe and convenient physical method of treatment. It may alleviate sleep disorders, depression, cognitive function, and other clinical symptoms. However, some studies have reported limited or no effects. Therefore, LT represents an attractive therapeutic approach for further investigation in ND. LT is an effective physical form of therapy and a new direction for research into treatments for ND. However, it requires further animal experiments to elucidate mechanisms of action and large, double-blind, randomized, and controlled trials to explore true efficacy in patients with ND.

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